Symptoms included memory loss, disorientation, and reduced mental energy.Īnother common symptom of Long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by excessive and persistent fatigue, inability to perform physical exercise, and autonomic dysregulation. Interestingly, an intelligence test in the United Kingdom detected cognitive impairments in a significant number of individuals with COVID-19. In long COVID, brain fog is a general term used to define impaired cognitive function, such as difficulty concentrating, loss of working and short-term memory, and difficulty with verbal and non-verbal methods of learning and mathematical problem-solving.Īlthough brain fog can be a consequence of various factors such as sleep deprivation, malnutrition, pregnancy or menopause-related hormonal changes, or even chemotherapy, it was the most reported symptom among COVID-19-recovering patients with no history of other diseases or hypoxia. Melatonin could potentially be a therapeutic agent in treating long COVID symptoms. It is also involved in the activation of glutathione-synthesizing enzymes. It has been found that melatonin is a cryoprotective hormone and chemical that exhibits anti-inflammatory, antioxidant, and immunoregulatory activity and has been seen to impair viral infections, play a role in circadian rhythm maintenance, and be effective against diabetes mellitus and cardiovascular diseases. This indicates that vaccination provides only limited protection against long COVID contrary to claims by those controlling the COVID-19 narratives. H incidence of long COVID symptoms such as deteriorated musculoskeletal, neurological, and mental health among these individuals after recovery. Interestingly, recent studies that examined vaccinated individuals who experienced breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections found a hig Patients who have recovered from severe COVID-19 experience these debilitating symptoms for months or years after recovery and even those who were initially asymptomatic and mildly symptomatic are witnessing a variety of Long COVID manifestations. Long COVID is becoming a growing concern associated with COVID-19 pandemic as it is now projected that as much as about 3 billion people around the world have been exposed to the SARS-CoV-2 virus knowingly or unknowingly with many experiencing post-infection chronic fatigue, memory loss, muscle weakness, reduced pulmonary capacity during exertion, persistent fever, myalgia, epileptic seizures, stroke, and other cardiovascular complications. This is the first study to discuss the potential uses of melatonin in treating brain fog and chronic fatigue syndrome or myalgic encephalomyelitis symptoms associated with long coronavirus disease (COVID). The study findings cum review were published in the peer reviewed journal: Biomolecules. Further studies on the therapeutic use of melatonin in the neurological sequelae of SARS-CoV-2 infection are warranted. The study findings discuss the application of melatonin as a neuroprotective agent to control cognitive deterioration (“brain fog”) and pain in the ME/CFS syndrome-like documented in long COVID. Melatonin is also a chronobiotic medication effective in treating delirium and restoring the circadian imbalance seen in COVID patients in the intensive care unit.įurthermore, as a cytoprotector, melatonin aids in the prevention of several COVID-19 comorbidities, including diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases.
It has been found that among the long-term consequences of SARS-CoV-2 infection, cognitive issues (especially memory loss or “brain fog”), chronic fatigue, myalgia, and muscular weakness resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are of importance.Īccording to the Long COVID Treatments study team, melatonin may be particularly effective at reducing the signs and symptoms of SARS-CoV-2 infection due to its functions as an antioxidant, anti-inflammatory, and immuno-modulatory agent. The clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger for months beyond the acute stage of SARS-CoV-2 infection and is commonly known as “long COVID”. Being a cheap generic supplement that is easily available, the study team suggested that melatonin can easily be included in Long COVID treatment protocols. Long COVID Treatments: A new multinational study involving researchers from Pontificia Universidad Católica - Argentina, University of Toronto - Canada and Saveetha University, Chennai – India has found that melatonin supplements can aid in relieving and treating certain Long COVID symptoms.
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